D-Aspartate Modulates Nociceptive-Specific Neuron Activity and Pain Threshold in Inflammatory and Neuropathic Pain Condition in Mice

D-Aspartate (D-Asp) is a free D-amino acid found in the mammalian brain with a temporal-dependent concentration based on the postnatal expression of its metabolizing enzyme D-aspartate oxidase (DDO). D-Asp acts as an agonist on NMDA receptors (NMDARs). Accordingly, high levels of D-Asp in knockout m...

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Bibliographic Details
Published in:Biomed Res Int
Main Authors: Boccella, Serena, Vacca, Valentina, Errico, Francesco, Marinelli, Sara, Squillace, Marta, Guida, Francesca, Di Maio, Anna, Vitucci, Daniela, Palazzo, Enza, De Novellis, Vito, Maione, Sabatino, Pavone, Flaminia, Usiello, Alessandro
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299315/
https://ncbi.nlm.nih.gov/pubmed/25629055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/905906
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