Antiviral Action and Cellular Toxicity of Four Thymidine Analogues: 5-Ethyl-, 5-Vinyl-, 5-Propyl-, and 5-Allyl-2′-Deoxyuridine

5-Ethyl-, 5-vinyl-, 5-propyl-, and 5-allyl-2′-deoxyuridine (dUrd) had antiviral activity against herpes simplex type 1 and type 2 grown in HeLa TK(−) cells, in the order 5-vinyl-dUrd, 5-ethyl-dUrd, 5-propyl-dUrd, 5-allyl-dUrd, but they were inactive against a TK(−) mutant of herpes simplex type 1. T...

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Bibliographic Details
Main Authors: Cheng, Yung-Chi, Domin, Barbara A., Sharma, Ram A., Bobek, Miroslav
Format: Artigo
Language:Inglês
Published: 1976
Subjects:
Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC429699/
https://ncbi.nlm.nih.gov/pubmed/185944
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