Antiviral Activity of Arabinosyladenine and Arabinosylhypoxanthine in Herpes Simplex Virus-Infected KB Cells: Selective Inhibition of Viral Deoxyribonucleic Acid Synthesis in Synchronized Suspension Cultures

The drug 9-β-d-arabinofuranosyladenine (ara-A) significantly suppressed the formation of herpes simplex virus type 1-induced syncytia in BHK-21/4 cells at concentrations as low as 0.1 μg/ml. Optimal activity was noted when the drug was added before initiation of viral deoxyribonucleic acid (DNA) syn...

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Detalles Bibliográficos
Main Authors: Shipman, Charles, Smith, Sandra H., Carlson, Roger H., Drach, John C.
Formato: Artigo
Idioma:Inglês
Publicado: 1976
Assuntos:
Chemistry; Mechanisms of Action and Resistance
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC429485/
https://ncbi.nlm.nih.gov/pubmed/176927
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