Antiviral Activity of Arabinosyladenine and Arabinosylhypoxanthine in Herpes Simplex Virus-Infected KB Cells: Selective Inhibition of Viral Deoxyribonucleic Acid Synthesis in Synchronized Suspension Cultures

The drug 9-β-d-arabinofuranosyladenine (ara-A) significantly suppressed the formation of herpes simplex virus type 1-induced syncytia in BHK-21/4 cells at concentrations as low as 0.1 μg/ml. Optimal activity was noted when the drug was added before initiation of viral deoxyribonucleic acid (DNA) syn...

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Bibliographic Details
Main Authors: Shipman, Charles, Smith, Sandra H., Carlson, Roger H., Drach, John C.
Format: Artigo
Language:Inglês
Published: 1976
Subjects:
Chemistry; Mechanisms of Action and Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC429485/
https://ncbi.nlm.nih.gov/pubmed/176927
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