Paternal heterochromatin formation in human embryos is H3K9/HP1 directed and primed by sperm-derived histone modifications

The different configurations of maternal and paternal chromatin, acquired during oogenesis and spermatogenesis, have to be rearranged after fertilization to form a functional embryonic genome. In the paternal genome, nucleosomal chromatin domains are re-established after the protamine-to-histone exc...

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Pubblicato in:Nat Commun
Autori principali: van de Werken, Christine, van der Heijden, Godfried W., Eleveld, Cindy, Teeuwssen, Miriam, Albert, Mareike, Baarends, Willy M., Laven, Joop S. E., Peters, Antoine H. F. M., Baart, Esther B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284653/
https://ncbi.nlm.nih.gov/pubmed/25519718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6868
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