GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake

Serotonin (5-HT) transporter (SERT) regulates the level of 5-HT in placenta. Initially, we found that in gestational diabetes mellitus (GDM), whereas free plasma 5-HT levels were elevated, the 5-HT uptake rates of trophoblast were significantly down-regulated, due to impairment in the translocation...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Li, Yicong, Hadden, Coedy, Singh, Preeti, Mercado, Charles P., Murphy, Pamela, Dajani, Nafisa K., Lowery, Curtis L., Roberts, Drucilla J., Maroteaux, Luc, Kilic, Fusun
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284607/
https://ncbi.nlm.nih.gov/pubmed/25512553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416675112
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