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Pre-steady-state Kinetic and Structural Analysis of Interaction of Methionine γ-Lyase from Citrobacter freundii with Inhibitors

Methionine γ-lyase (MGL) catalyzes the γ-elimination of l-methionine and its derivatives as well as the β-elimination of l-cysteine and its analogs. These reactions yield α-keto acids and thiols. The mechanism of chemical conversion of amino acids includes numerous reaction intermediates. The detail...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Kuznetsov, Nikita A., Faleev, Nicolai G., Kuznetsova, Alexandra A., Morozova, Elena A., Revtovich, Svetlana V., Anufrieva, Natalya V., Nikulin, Alexei D., Fedorova, Olga S., Demidkina, Tatyana V.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2015
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281767/
https://ncbi.nlm.nih.gov/pubmed/25398880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.586511
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