An internal ribosome entry site in the 5′ untranslated region of epidermal growth factor receptor allows hypoxic expression

The expression of epidermal growth factor receptor (EGFR/ERBB1/HER1) is implicated in the progress of numerous cancers, a feature that has been exploited in the development of EGFR antibodies and EGFR tyrosine kinase inhibitors as anti-cancer drugs. However, EGFR also has important normal cellular f...

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Veröffentlicht in:Oncogenesis
Hauptverfasser: Webb, T E, Hughes, A, Smalley, D S, Spriggs, K A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
Schlagworte:
Short Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4275558/
https://ncbi.nlm.nih.gov/pubmed/25622307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2014.43
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