Azithromycin suppresses CD4(+) T-cell activation by direct modulation of mTOR activity

Advanced macrolides, such as azithromycin (AZM) or clarithromycin (CLM), are antibiotics with immunomodulatory properties. Here we have sought to evaluate their in vitro influence on the activation of CD4(+) T-cells. Isolated CD4(+) T-cells were stimulated with agonistic anti-CD3/anti-CD28 monoclona...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Ratzinger, F., Haslacher, H., Poeppl, W., Hoermann, G., Kovarik, J. J., Jutz, S., Steinberger, P., Burgmann, H., Pickl, W. F., Schmetterer, K. G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262884/
https://ncbi.nlm.nih.gov/pubmed/25500904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07438
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