Azithromycin suppresses CD4(+) T-cell activation by direct modulation of mTOR activity

Advanced macrolides, such as azithromycin (AZM) or clarithromycin (CLM), are antibiotics with immunomodulatory properties. Here we have sought to evaluate their in vitro influence on the activation of CD4(+) T-cells. Isolated CD4(+) T-cells were stimulated with agonistic anti-CD3/anti-CD28 monoclona...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Ratzinger, F., Haslacher, H., Poeppl, W., Hoermann, G., Kovarik, J. J., Jutz, S., Steinberger, P., Burgmann, H., Pickl, W. F., Schmetterer, K. G.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262884/
https://ncbi.nlm.nih.gov/pubmed/25500904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07438
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