PI3K Regulation of RAC1 is Required for KRAS-induced Pancreatic Tumorigenesis in Mice

BACKGROUND & AIMS: New drug targets are urgently needed for the treatment of pancreatic ductal adenocarcinoma (PDA). Nearly all PDAs contain oncogenic mutations in the KRAS gene. Pharmacologic inhibition of KRAS has been unsuccessful, leading to a focus on downstream effectors that are more easi...

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Vydáno v:Gastroenterology
Hlavní autoři: Wu, Chia-Yen C., Carpenter, Eileen S., Takeuchi, Kenneth K., Halbrook, Christopher J., Peverley, Louise V., Bien, Harold, Hall, Jason C., DelGiorno, Kathleen E., Pal, Debjani, Song, Yan, Shi, Chanjuan, Lin, Richard Z., Crawford, Howard C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252806/
https://ncbi.nlm.nih.gov/pubmed/25311989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.08.032
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