PI3K Regulation of RAC1 is Required for KRAS-induced Pancreatic Tumorigenesis in Mice

BACKGROUND & AIMS: New drug targets are urgently needed for the treatment of pancreatic ductal adenocarcinoma (PDA). Nearly all PDAs contain oncogenic mutations in the KRAS gene. Pharmacologic inhibition of KRAS has been unsuccessful, leading to a focus on downstream effectors that are more easi...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Gastroenterology
Main Authors: Wu, Chia-Yen C., Carpenter, Eileen S., Takeuchi, Kenneth K., Halbrook, Christopher J., Peverley, Louise V., Bien, Harold, Hall, Jason C., DelGiorno, Kathleen E., Pal, Debjani, Song, Yan, Shi, Chanjuan, Lin, Richard Z., Crawford, Howard C.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252806/
https://ncbi.nlm.nih.gov/pubmed/25311989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.08.032
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker