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Blockade of excitatory synaptogenesis with proximal dendrites of dentate granule cells following rapamycin treatment in a mouse model of temporal lobe epilepsy

Inhibiting the mTOR signaling pathway with rapamycin blocks granule cell axon (mossy fiber) sprouting after epileptogenic injuries, including pilocarpine-induced status epilepticus. However, it remains unclear whether axons from other types of neurons sprout into the inner molecular layer and synaps...

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Vydáno v:J Comp Neurol
Hlavní autoři: Yamawaki, Ruth, Thind, Khushdev, Buckmaster, Paul S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252507/
https://ncbi.nlm.nih.gov/pubmed/25234294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cne.23681
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