Causes and consequences of microsatellite instability in gastric carcinogenesis

Loss of DNA mismatch repair (MMR) function, due to somatic or germline epi/genetic alterations of MMR genes leads to the accumulation of numerous mutations across the genome, creating a molecular phenotype known as microsatellite instability (MSI). In gastric cancer (GC), MSI occurs in about 15% to...

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Udgivet i:World J Gastroenterol
Main Authors: Velho, Sérgia, Fernandes, Maria Sofia, Leite, Marina, Figueiredo, Ceu, Seruca, Raquel
Format: Artigo
Sprog:Inglês
Udgivet: Baishideng Publishing Group Inc 2014
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248186/
https://ncbi.nlm.nih.gov/pubmed/25469011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v20.i44.16433
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