Synthesis and Biological Evaluation of QRSTUVWXYZA′ Domains of Maitotoxin

[Image: see text] The synthesis of QRSTUVWXYZA′ domains 7, 8, and 9 of the highly potent marine neurotoxin maitotoxin (1), the largest secondary metabolite isolated to date, is described. The devised synthetic strategy entailed a cascade Takai–Utimoto ester olefination/ring closing metathesis to con...

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Detaylı Bibliyografya
Yayımlandı:J Am Chem Soc
Asıl Yazarlar: Nicolaou, K. C., Heretsch, Philipp, Nakamura, Tsuyoshi, Rudo, Anna, Murata, Michio, Konoki, Keiichi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2014
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4244842/
https://ncbi.nlm.nih.gov/pubmed/25374117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja509829e
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