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CCDI: a new ligand that modulates mammalian type 1 ryanodine receptor (RyR1)

BACKGROUND AND PURPOSE: Ryanodine receptors (RyRs) are Ca(2+)-release channels on the sarco(endo)plasmic reticulum that modulate a wide array of physiological functions. Three RyR isoforms are present in cells: RyR1, RyR2 and RyR3. To date, there are no reports on ligands that modulate RyR in an iso...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Tian, Chengju, Shao, Chun Hong, Padanilam, Christina, Ezell, Edward, Singh, Jaipaul, Kutty, Shelby, Bidasee, Keshore R
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243982/
https://ncbi.nlm.nih.gov/pubmed/24819467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12764
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