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The development of orally administrable gemcitabine prodrugs with D-enantiomer amino acids: Enhanced membrane permeability and enzymatic stability

Gemcitabine prodrugs with D- and L-configuration amino acids were synthesized and their chemical stability in buffers, resistance to glycosidic bond metabolism, enzymatic activation, permeability in Caco-2 cells and mouse intestinal membrane, anti-proliferation activity in cancer cell were determine...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Eur J Pharm Biopharm
मुख्य लेखकों: Tsume, Yasuhiro, Incecayir, Tuba, Song, Xueqin, Hilfinger, John M., Amidon, Gordon L.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2013
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243704/
https://ncbi.nlm.nih.gov/pubmed/24361461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejpb.2013.12.009
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