DNA From Dead Cancer Cells Induces TLR9-Mediated Invasion and Inflammation In Living Cancer Cells

TLR9 is a cellular DNA-receptor, which is widely expressed in breast and other cancers. Although synthetic TLR9-ligands induce cancer cell invasion in vitro, the role of TLR9 in cancer pathophysiology has remained unclear. We show here that living cancer cells uptake DNA from chemotherapy-killed can...

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Bibliografiska uppgifter
I publikationen:Breast Cancer Res Treat
Huvudupphovsmän: Tuomela, Johanna, Sandholm, Jouko, Kaakinen, Mika, Patel, Ankita, Kauppila, Joonas H., Ilvesaro, Joanna, Chen, Dongquan, Harris, Kevin W., Graves, David, Selander, Katri S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4238912/
https://ncbi.nlm.nih.gov/pubmed/24212717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-013-2762-0
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