PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways

The PI3K/Akt/mTOR pathway has a central role in cancer metastasis and radiotherapy. To develop effective therapeutics to improve radiosensitivity, understanding the possible pathways of radioresistance involved and the effects of a combination of the PI3K/Akt/mTOR inhibitors with radiotherapy on pro...

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Vydáno v:Cell Death Dis
Hlavní autoři: Chang, L, Graham, P H, Hao, J, Ni, J, Bucci, J, Cozzi, P J, Kearsley, J H, Li, Y
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237243/
https://ncbi.nlm.nih.gov/pubmed/25275598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.415
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