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The change in Ig regulation from children to adults disconnects the correlation with the 3′RR hs1.2 polymorphism
BACKGROUND: In the immune system, the serum levels of immunoglobulin (Ig) increase gradually during ageing. Through B cell development, the Ig heavy chain expression is modulated by a regulatory region at the 3’ of the constant alpha gene (3’RR), in single copy in rodents and, due to a large duplica...
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Pubblicato in: | BMC Immunol |
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Autori principali: | , , , , , , , , , , , , , |
Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
BioMed Central
2014
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Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4234878/ https://ncbi.nlm.nih.gov/pubmed/25391515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12865-014-0045-0 |
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