The change in Ig regulation from children to adults disconnects the correlation with the 3′RR hs1.2 polymorphism

BACKGROUND: In the immune system, the serum levels of immunoglobulin (Ig) increase gradually during ageing. Through B cell development, the Ig heavy chain expression is modulated by a regulatory region at the 3’ of the constant alpha gene (3’RR), in single copy in rodents and, due to a large duplica...

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Veröffentlicht in:BMC Immunol
Hauptverfasser: Serone, Eliseo, Daleno, Cristina, Principi, Nicola, Porretti, Laura, Iacoacci, Valentina, Gargioli, Cesare, Magrini, Andrea, Massoud, Renato, D’Addabbo, Pietro, Cattalini, Marco, Giambra, Vincenzo, Plebani, Alessandro, Esposito, Susanna, Frezza, Domenico
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234878/
https://ncbi.nlm.nih.gov/pubmed/25391515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12865-014-0045-0
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