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Evaluation of Antitrypanosomal Dihydroquinolines for Hepatotoxicity, Mutagenicity, and Methemoglobin Formation In Vitro

N 1-benzylated dihydroquinolin-6-ols and their corresponding esters display exceptional activity against African trypanosomes in vitro, and administration of members of this class of compounds to trypanosome-infected mice results in cures in a first stage African trypanosomiasis model. Since a quino...

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Bibliografiske detaljer
Udgivet i:Int J Toxicol
Main Authors: Werbovetz, Karl A., Riccio, Edward S., Furimsky, Anna, Richard, Julian V., He, Shanshan, Iyer, Lalitha, Mirsalis, Jon
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4229492/
https://ncbi.nlm.nih.gov/pubmed/24819520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1091581814533971
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