A spatial simulation approach to account for protein structure when identifying non-random somatic mutations

BACKGROUND: Current research suggests that a small set of “driver” mutations are responsible for tumorigenesis while a larger body of “passenger” mutations occur in the tumor but do not progress the disease. Due to recent pharmacological successes in treating cancers caused by driver mutations, a va...

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Bibliografiske detaljer
Udgivet i:BMC Bioinformatics
Main Authors: Ryslik, Gregory A, Cheng, Yuwei, Cheung, Kei-Hoi, Bjornson, Robert D, Zelterman, Daniel, Modis, Yorgo, Zhao, Hongyu
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Methodology Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227039/
https://ncbi.nlm.nih.gov/pubmed/24990767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-15-231
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