SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria

Sodium glucose cotransporter 2 (SGLT2) inhibitors have been reported to lower the serum uric acid (SUA) level. To elucidate the mechanism responsible for this reduction, SUA and the urinary excretion rate of uric acid (UE(UA)) were analysed after the oral administration of luseogliflozin, a SGLT2 in...

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Bibliographische Detailangaben
Veröffentlicht in:Biopharm Drug Dispos
Hauptverfasser: Chino, Yukihiro, Samukawa, Yoshishige, Sakai, Soichi, Nakai, Yasuhiro, Yamaguchi, Jun-ichi, Nakanishi, Takeo, Tamai, Ikumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2014
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Original Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223977/
https://ncbi.nlm.nih.gov/pubmed/25044127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdd.1909
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