Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies

Clinical and neuropathological similarities between dementia with Lewy bodies (DLB), Parkinson's and Alzheimer's diseases (PD and AD, respectively) suggest that these disorders may share etiology. To test this hypothesis, we have performed an association study of 54 genomic regions, previo...

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Publicat a:Hum Mol Genet
Autors principals: Bras, Jose, Guerreiro, Rita, Darwent, Lee, Parkkinen, Laura, Ansorge, Olaf, Escott-Price, Valentina, Hernandez, Dena G., Nalls, Michael A., Clark, Lorraine N., Honig, Lawrence S., Marder, Karen, Van Der Flier, Wiesje M., Lemstra, Afina, Scheltens, Philip, Rogaeva, Ekaterina, St George-Hyslop, Peter, Londos, Elisabet, Zetterberg, Henrik, Ortega-Cubero, Sara, Pastor, Pau, Ferman, Tanis J., Graff-Radford, Neill R., Ross, Owen A., Barber, Imelda, Braae, Anne, Brown, Kristelle, Morgan, Kevin, Maetzler, Walter, Berg, Daniela, Troakes, Claire, Al-Sarraj, Safa, Lashley, Tammaryn, Compta, Yaroslau, Revesz, Tamas, Lees, Andrew, Cairns, Nigel, Halliday, Glenda M., Mann, David, Pickering-Brown, Stuart, Dickson, Dennis W., Singleton, Andrew, Hardy, John
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222357/
https://ncbi.nlm.nih.gov/pubmed/24973356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu334
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