The structural basis of urea-induced protein unfolding in β-catenin

Although urea and guanidine hydrochloride are commonly used to denature proteins, the molecular underpinnings of this process have remained unclear for a century. To address this question, crystal structures of β-catenin were determined at various urea concentrations. These structures contained at l...

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Udgivet i:Acta Crystallogr D Biol Crystallogr
Main Authors: Wang, Chao, Chen, Zhongzhou, Hong, Xia, Ning, Fangkun, Liu, Haolin, Zang, Jianye, Yan, Xiaoxue, Kemp, Jennifer, Musselman, Catherine A., Kutateladze, Tatinna G., Zhao, Rui, Jiang, Chengyu, Zhang, Gongyi
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2014
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4220971/
https://ncbi.nlm.nih.gov/pubmed/25372676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004714018094
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