CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors

Truncating mutations of chromodomain helicase DNA-binding protein 8 (CHD8), and of many other genes with diverse functions, are strong-effect risk factors for autism spectrum disorder (ASD), suggesting multiple mechanisms of pathogenesis. We explored the transcriptional networks that CHD8 regulates...

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Hlavní autoři: Sugathan, Aarathi, Biagioli, Marta, Golzio, Christelle, Erdin, Serkan, Blumenthal, Ian, Manavalan, Poornima, Ragavendran, Ashok, Brand, Harrison, Lucente, Diane, Miles, Judith, Sheridan, Steven D., Stortchevoi, Alexei, Kellis, Manolis, Haggarty, Stephen J., Katsanis, Nicholas, Gusella, James F., Talkowski, Michael E.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210312/
https://ncbi.nlm.nih.gov/pubmed/25294932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405266111
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