Kinase Domain Point Mutations in Ph+ Acute Lymphoblastic Leukemia (ALL) Emerge Following Therapy with BCR-ABL Kinase Inhibitors

BACKGROUND: BCR-ABL kinase domain (KD) mutations are detected in approximately 45% of imatinib-resistant CML. Patterns of KD mutations in Philadelphia chromosome (Ph)+ acute lymphoblastic leukemia (ALL) are less well-studied. METHODS: We assessed KD mutations in relapsed Ph+ ALL following treatments...

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Main Authors: Jones, Dan, Thomas, Deborah, Yin, C. Cameron, O'Brien, Susan, Cortes, Jorge E., Jabbour, Elias, Breeden, Megan, Giles, Francis J., Zhao, Weiqiang, Kantarjian, Hagop M.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4204653/
https://ncbi.nlm.nih.gov/pubmed/18615627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.23666
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