DYRK1A phoshorylates histone H3 to differentially regulate the binding of HP1 isoforms and antagonize HP1-mediated transcriptional repression

Heterochromatin protein 1 (HP1) proteins are chromatin-bound transcriptional regulators. While their chromodomain binds histone H3 methylated on lysine 9, their chromoshadow domain associates with the H3 histone fold in a region involved in chromatin remodeling. Here, we show that phosphorylation at...

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Main Authors: Jang, Suk Min, Azebi, Saliha, Soubigou, Guillaume, Muchardt, Christian
Formáid: Artigo
Teanga:Inglês
Foilsithe: BlackWell Publishing Ltd 2014
Ábhair:
Scientific Reports
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197879/
https://ncbi.nlm.nih.gov/pubmed/24820035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201338356
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