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Enantioselective Synthesis and Profiling of Two Novel Diazabicyclooctanone β-Lactamase Inhibitors

[Image: see text] The enantioselective synthesis of two novel cyclopropane-fused diazabicyclooctanones is reported here. Starting from butadiene monoxide, the key enone intermediate 7 was prepared in six steps. Subsequent stereoselective introduction of the cyclopropane group and further transformat...

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Autori principali: Xiong, Hui, Chen, Brendan, Durand-Réville, Thomas F., Joubran, Camil, Alelyunas, Yun W., Wu, Dedong, Huynh, Hoan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190641/
https://ncbi.nlm.nih.gov/pubmed/25313328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500284k
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