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Crystal Structures and Structure–Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors
[Image: see text] Indoleamine 2,3-dioxygenase 1 (IDO1) is considered as a promising target for the treatment of several diseases, including neurological disorders and cancer. We report here the crystal structures of two IDO1/IDO1 inhibitor complexes, one of which shows that Amg-1 is directly bound t...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Chemical
Society
2014
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4190630/ https://ncbi.nlm.nih.gov/pubmed/25313323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500247w |
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