Crystal Structures and Structure–Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors

[Image: see text] Indoleamine 2,3-dioxygenase 1 (IDO1) is considered as a promising target for the treatment of several diseases, including neurological disorders and cancer. We report here the crystal structures of two IDO1/IDO1 inhibitor complexes, one of which shows that Amg-1 is directly bound t...

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Autors principals: Tojo, Shingo, Kohno, Tetsuya, Tanaka, Tomoyuki, Kamioka, Seiji, Ota, Yosuke, Ishii, Takayuki, Kamimoto, Keiko, Asano, Shigehiro, Isobe, Yoshiaki
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190630/
https://ncbi.nlm.nih.gov/pubmed/25313323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500247w
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