Involvement of Tumor Macrophage HIFs in Chemotherapy Effectiveness: Mathematical Modeling of Oxygen, pH, and Glutathione

The four variables, hypoxia, acidity, high glutathione (GSH) concentration and fast reducing rate (redox) are distinct and varied characteristics of solid tumors compared to normal tissue. These parameters are among the most significant factors underlying the metabolism and physiology of solid tumor...

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Detalhes bibliográficos
Main Authors: Chen, Duan, Bobko, Andrey A., Gross, Amy C., Evans, Randall, Marsh, Clay B., Khramtsov, Valery V., Eubank, Timothy D., Friedman, Avner
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4189793/
https://ncbi.nlm.nih.gov/pubmed/25295611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107511
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