The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT(7) receptor binding and cAMP signaling

We performed a detailed in vitro pharmacological characterization of two arylpiperazine derivatives, compound N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide (LP-211) previously identified as a high-affinity brain penetrant ligand for 5-hydroxytryptamine (serotonin) type 7 (5-HT(7)) re...

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Главные авторы: Atanes, Patricio, Lacivita, Enza, Rodríguez, Javier, Brea, José, Burgueño, Javier, Vela, José Miguel, Cadavid, María Isabel, Loza, María Isabel, Leopoldo, Marcello, Castro, Marián
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Publishing Ltd 2013
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186431/
https://ncbi.nlm.nih.gov/pubmed/25505568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.13
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