Deletion of CD24 impairs development of heat shock protein gp96 -driven autoimmune disease through expansion of myeloid derived suppressor cells

CD24 binds to and suppresses inflammation triggered by danger associated molecular patterns (DAMPS) such as heat-shock proteins (HSPs) and HMGB1. Paradoxically, CD24 has been shown to enhance autoimmune disease. Here we attempt to reconcile this paradox by deletion of CD24 (24KO) in a lupus-like dis...

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Bibliographic Details
Main Authors: Thaxton, Jessica E, Liu, Bei, Zheng, Pan, Liu, Yang, Li, Ziha
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4185284/
https://ncbi.nlm.nih.gov/pubmed/24808359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302755
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