()The autoinhibitory C-terminal SH2 domain of phospholipase C–γ2 stabilizes B cell receptor signalosome assembly

The binding of antigen to the B cell receptor (BCR) stimulates the assembly of a signaling complex (signalosome) composed initially of the kinases Lyn, spleen tyrosine kinase (Syk), and Bruton’s tyrosine kinase (Btk), as well as the adaptor protein B cell linker (BLNK). Together, these proteins recr...

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Bibliographic Details
Main Authors: Wang, Jing, Sohn, Haewon, Sun, Guangping, Milner, Joshua D., Pierce, Susan K.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180509/
https://ncbi.nlm.nih.gov/pubmed/25227611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005392
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