Cyclic compressive loading on 3D tissue of human synovial fibroblasts upregulates prostaglandin E2 via COX-2 production without IL-1β and TNF-α

OBJECTIVE: Excessive mechanical stress on synovial joints causes osteoarthritis (OA) and results in the production of prostaglandin E2 (PGE2), a key molecule in arthritis, by synovial fibroblasts. However, the relationship between arthritis-related molecules and mechanical stress is still unclear. T...

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Détails bibliographiques
Auteurs principaux: Shimomura, K., Kanamoto, T., Kita, K., Akamine, Y., Nakamura, N., Mae, T., Yoshikawa, H., Nakata, K.
Format: Artigo
Langue:Inglês
Publié: British Editorial Society of Bone and Joint Surgery 2014
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178306/
https://ncbi.nlm.nih.gov/pubmed/25237168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1302/2046-3758.39.2000287
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