Mediodorsal Thalamus Hypofunction Impairs Flexible Goal-Directed Behavior

BACKGROUND: Cognitive inflexibility is a core symptom of several mental disorders including schizophrenia. Brain imaging studies in schizophrenia patients performing cognitive tasks have reported decreased activation of the mediodorsal thalamus (MD). Using a pharmacogenetic approach to model MD hypo...

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Main Authors: Parnaudeau, Sébastien, Taylor, Kathleen, Bolkan, Scott S., Ward, Ryan D., Balsam, Peter D., Kellendonk, Christoph
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177020/
https://ncbi.nlm.nih.gov/pubmed/24813335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2014.03.020
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