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Mice Deficient in NF-κB p50 and p52 or RANK Have Defective Growth Plate Formation and Post-natal Dwarfism

NF-κBp50/p52 double knockout (dKO) and RANK KO mice have no osteoclasts and develop severe osteopetrosis associated with dwarfism. In contrast, Op/Op mice, which form few osteoclasts, and Src KO mice, which have osteoclasts with defective resorptive function, are osteopetrotic, but they are not dwar...

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Detalhes bibliográficos
Main Authors: Xing, Lianping, Chen, Di, Boyce, Brendan F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175530/
https://ncbi.nlm.nih.gov/pubmed/26273511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4248/BR201304004
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