Allopregnanolone and Its Precursor Progesterone Do Not Reduce Injury after Experimental Stroke in Hypertensive Rats – Role of Postoperative Temperature Regulation?

Allopregnanolone is a neurosteroid synthesized from progesterone in brain. It increases inhibition through modulation of the gamma-aminobutyric acid type A (GABA-A) receptor. Both agents are putative neuroprotectants after ischemic stroke. We sought to confirm their effectiveness in a hypertensive r...

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Autores principales: Spratt, Neil J., Tomkins, Amelia J., Pepperall, Debbie, McLeod, Damian D., Calford, Mike B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172598/
https://ncbi.nlm.nih.gov/pubmed/25248155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0107752
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