Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET

Dysregulation of the von Hippel–Lindau/hypoxia-inducible transcription factor (HIF) signaling pathway promotes clear cell renal cell carcinoma (ccRCC) progression and metastasis. The protein kinase GAS6/AXL signaling pathway has recently been implicated as an essential mediator of metastasis and rec...

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Hlavní autoři: Rankin, Erinn B., Fuh, Katherine C., Castellini, Laura, Viswanathan, Kartik, Finger, Elizabeth C., Diep, Anh N., LaGory, Edward L., Kariolis, Mihalis S., Chan, Andy, Lindgren, David, Axelson, Håkan, Miao, Yu R., Krieg, Adam J., Giaccia, Amato J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169907/
https://ncbi.nlm.nih.gov/pubmed/25187556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1404848111
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