A Novel KCNJ5-insT149 Somatic Mutation Close to, but Outside, the Selectivity Filter Causes Resistant Hypertension by Loss of Selectivity for Potassium

CONTEXT: Understanding the function of the KCNJ5 potassium channel through characterization of naturally occurring novel mutations is key for dissecting the mechanism(s) of autonomous aldosterone secretion in primary aldosteronism. OBJECTIVE: We sought for such novel KCNJ5 channel mutations in a lar...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Kuppusamy, Maniselvan, Caroccia, Brasilina, Stindl, Julia, Bandulik, Sascha, Lenzini, Livia, Gioco, Francesca, Fishman, Veniamin, Zanotti, Giuseppe, Gomez-Sanchez, Celso, Bader, Michael, Warth, Richard, Rossi, Gian Paolo
التنسيق: Artigo
اللغة:Inglês
منشور في: Endocrine Society 2014
الموضوعات:
JCEM Online: Advances in Genetics
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154085/
https://ncbi.nlm.nih.gov/pubmed/25057880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2014-1927
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