Reduced Renal Clearance of Cefotaxime in Asians with a Low-Frequency Polymorphism of OAT3 (SLC22A8)

Organic anion transporter 3 (OAT3, SLC22A8), a transporter expressed on the basolateral membrane of the proximal tubule, plays a critical role in the renal excretion of organic anions including many therapeutic drugs. The goal of this study was to evaluate the in vivo effects of the OAT3-Ile305Phe v...

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Bibliografiske detaljer
Main Authors: Yee, Sook Wah, Nguyen, Anh Nguyet, Brown, Chaline, Savic, Radojka M., Zhang, Youcai, Castro, Richard A., Cropp, Cheryl D., Choi, Ji Ha, Singh, Diment, Tahara, Harunobu, Stocker, Sophie L., Huang, Yong, Brett, Claire M., Giacomini, Kathleen M.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151246/
https://ncbi.nlm.nih.gov/pubmed/23649425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23581
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