Relationships between Signaling Pathway Usage and Sensitivity to a Pathway Inhibitor: Examination of Trametinib Responses in Cultured Breast Cancer Lines

Cellular signaling pathways involving mTOR, PI3K and ERK have dominated recent studies of breast cancer biology, and inhibitors of these pathways have formed a focus of numerous clinical trials. We have chosen trametinib, a drug targeting MEK in the ERK pathway, to address two questions. Firstly, do...

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Bibliographic Details
Main Authors: Leung, Euphemia Y., Kim, Ji Eun, Askarian-Amiri, Marjan, Rewcastle, Gordon W., Finlay, Graeme J., Baguley, Bruce C.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149495/
https://ncbi.nlm.nih.gov/pubmed/25170609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105792
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