Coupling of G Proteins to Reconstituted Monomers and Tetramers of the M(2) Muscarinic Receptor

G protein-coupled receptors can be reconstituted as monomers in nanodiscs and as tetramers in liposomes. When reconstituted with G proteins, both forms enable an allosteric interaction between agonists and guanylyl nucleotides. Both forms, therefore, are candidates for the complex that controls sign...

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Autors principals: Redka, Dar'ya S., Morizumi, Takefumi, Elmslie, Gwendolynne, Paranthaman, Pranavan, Shivnaraine, Rabindra V., Ellis, John, Ernst, Oliver P., Wells, James W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148863/
https://ncbi.nlm.nih.gov/pubmed/25023280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.559294
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