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Accumulation of 4-1BBL(+) B cells in the elderly induces the generation of granzyme-B(+) CD8(+) T cells with potential antitumor activity
Although the accumulation of highly-differentiated and granzyme B (GrB)-expressing CD8(+)CD28(–) T cells has been associated with aging, the mechanism for their enrichment and contribution to immune function remains poorly understood. Here we report a novel B-cell subset expressing 4-1BBL, which inc...
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| Main Authors: | , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society of Hematology
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4148767/ https://ncbi.nlm.nih.gov/pubmed/25037628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-03-563940 |
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