Accumulation of 4-1BBL(+) B cells in the elderly induces the generation of granzyme-B(+) CD8(+) T cells with potential antitumor activity

Although the accumulation of highly-differentiated and granzyme B (GrB)-expressing CD8(+)CD28(–) T cells has been associated with aging, the mechanism for their enrichment and contribution to immune function remains poorly understood. Here we report a novel B-cell subset expressing 4-1BBL, which inc...

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Bibliographic Details
Main Authors: Lee-Chang, Catalina, Bodogai, Monica, Moritoh, Kanako, Olkhanud, Purevdorj B., Chan, Andrew C., Croft, Michael, Mattison, Julie A., Holst, Peter Johannes, Gress, Ronald E., Ferrucci, Luigi, Hakim, Fran, Biragyn, Arya
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2014
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148767/
https://ncbi.nlm.nih.gov/pubmed/25037628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-03-563940
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