Primary Seronegative but Molecularly Evident Hepadnaviral Infection Engages Liver and Induces Hepatocarcinoma in the Woodchuck Model of Hepatitis B

Hepadnavirus at very low doses establishes in woodchucks asymptomatic, serologically undetectable but molecularly evident persistent infection. This primary occult infection (POI) preferentially engages the immune system and initiates virus-specific T cell response in the absence of antiviral antibo...

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Main Authors: Mulrooney-Cousins, Patricia M., Chauhan, Ranjit, Churchill, Norma D., Michalak, Tomasz I.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148403/
https://ncbi.nlm.nih.gov/pubmed/25165821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004332
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