Elevated Heart Rate Triggers Action Potential Alternans and Sudden Death. Translational Study of a Homozygous KCNH2 Mutation

BACKGROUND: Long QT syndrome (LQTS) leads to arrhythmic events and increased risk for sudden cardiac death (SCD). Homozygous KCNH2 mutations underlying LQTS-2 have previously been termed “human HERG knockout” and typically express severe phenotypes. We studied genotype-phenotype correlations of an L...

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Detalhes bibliográficos
Main Authors: Schweigmann, Ulrich, Biliczki, Peter, Ramirez, Rafael J., Marschall, Christoph, Takac, Ina, Brandes, Ralf P., Kotzot, Dieter, Girmatsion, Zenawit, Hohnloser, Stefan H., Ehrlich, Joachim R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139196/
https://ncbi.nlm.nih.gov/pubmed/25140878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103150
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