A new mechanism of allostery in a G protein-coupled receptor dimer

SB269652 (1) is the first drug-like allosteric modulator of the dopamine D(2) receptor (D(2)R), but contains structural features associated with orthosteric D(2)R antagonists. Using a functional complementation system to control the identity of individual protomers within a dimeric D(2)R complex, we...

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Detalhes bibliográficos
Main Authors: Lane, J. Robert, Donthamsetti, Prashant, Shonberg, Jeremy, Draper-Joyce, Christopher J., Dentry, Samuel, Michino, Mayako, Shi, Lei, López, Laura, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Javitch, Jonathan A., Christopoulos, Arthur
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138267/
https://ncbi.nlm.nih.gov/pubmed/25108820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1593
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